β-Adrenoceptor mechanisms and drug development
نویسندگان
چکیده
منابع مشابه
epilepsy drug and effects on fetal development: potential mechanisms
normal 0 false false false en-us x-none ar-sa approximately 1% of all pregnancies are in woman with epilepsy. although, the majority of children born to women with epilepsy are normal, they are at increased risk for malformations. notably, the teratogenicity of antiepileptic drugs is a well-defined subject. the incidence of major malformations in offspring of mothers with epilepsy who were trea...
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Treatment with β-adrenoceptor agonists does not fully overcome the symptoms associated with severe asthma. Serelaxin elicits potent uterine and vascular relaxation via its cognate receptor, RXFP1, and nitric oxide (NO) signaling, and is being clinically evaluated for the treatment of acute heart failure. However, its direct bronchodilator efficacy has yet to be explored. Tracheal rings were pre...
متن کاملβ-Adrenoceptor-mediated Relaxation of Urinary Bladder Muscle in β2-Adrenoceptor Knockout Mice
BACKGROUND AND OBJECTIVE In order to characterize the β-adrenoceptor (AR) subtypes involved in agonist-stimulated relaxation of murine urinary bladder we studied the effects of (-)-isoprenaline and CL 316,243 on tonic contraction and spontaneous contractions in detrusor strips of wild-type (WT) and β2-AR knockout (β2-AR KO) mice. MATERIALS AND METHODS Urinary bladders were isolated from male ...
متن کاملβ-Adrenoceptor-Mediated Relaxation of Carbachol-Pre-Contracted Mouse Detrusor.
AIMS To study the β-adrenoceptor subtypes involved in the relaxation responses to (-)-isoprenaline in carbachol-pre-contracted (CCh) mouse detrusor muscle with intact and denuded mucosa. METHODS Isolated muscle strips from the urinary bladder of male C57BL6 mice or β2-adrenoceptor knockout mice were pre-contracted with CCh, 1 µM and relaxed with increasing concentrations of the β-adrenoceptor...
متن کاملPrescribing of β-adrenoceptor antagonists in asthma: an observational study.
BACKGROUND β-Antagonists have recently been proposed for the treatment of chronic asthma; however, concerns regarding risk of acute bronchoconstriction in clinical trials remain. OBJECTIVE To determine the frequency of oral β-blocker prescribing in patients with asthma and associations with severe asthma exacerbations requiring oral steroids in patients with active asthma defined by prior ast...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1997
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)33794-1